ANCA-Associated Vasculitis & Pulmonary-Renal Syndromes — Practice
A 28-year-old man presents with haemoptysis, haematuria, and bilateral pulmonary infiltrates on chest X-ray. Renal biopsy shows crescentic glomerulonephritis with linear IgG deposits along the glomerular basement membrane. Anti-GBM antibodies are positive. What is the first-line treatment?
AHigh-dose steroids alone
BMycophenolate mofetil and steroids
CRituximab monotherapy
DPlasmapheresis combined with cyclophosphamide and steroids