Anticholinesterases & Reversal Agents
ModerateAnaesthesia · Pharmacology
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Reversal of neuromuscular blockade is one of the most testable corners of anaesthesia pharmacology. The story revolves around two strategies — the classic anticholinesterases (neostigmine, pyridostigmine, edrophonium) that flood the synapse with acetylcholine, and the modern selective relaxant binding agent sugammadex that physically chelates the relaxant. Understanding the mechanisms, the obligatory anticholinergic …
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