Cardiac Glycosides
ModeratePharmacology · CVS
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Cardiac glycosides are steroid-derived drugs—digoxin being the only one in routine modern use—that inhibit the sarcolemmal Na⁺/K⁺-ATPase to produce a positive inotropic and negative chronotropic/dromotropic effect. They occupy a uniquely high-yield niche in pharmacology because of a razor-thin therapeutic index, a classic mechanism, and a textbook antidote (digoxin-specific Fab). This note builds the topic from molec…
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