Demyelinating Disorders

Demyelinating disorders are conditions in which the myelin sheath of central (CNS) or peripheral (PNS) nerves is destroyed while the axon is relatively spared, slowing or blocking saltatory conduction. For NEET PG the two superstar topics are multiple sclerosis (MS) — the prototype CNS demyelinating disease — and Guillain–Barré syndrome (GBS) — the prototype acquired PNS demyelinating disease. This note builds both s…