Drugs Used in Heart Failure — Practice
A 58-year-old man with heart failure with reduced ejection fraction is switched from an ACE inhibitor to sacubitril-valsartan. A mandatory washout period is required before starting this combination to reduce a specific risk. What is that risk?
AAngioedema from overlapping neprilysin and ACE inhibition
BHyperkalaemia from dual RAAS blockade
CFirst-dose hypotension from valsartan
DCough from bradykinin accumulation