Enzyme Kinetics & Inhibition — Practice
A research group studies a kinetic mutant of an enzyme that, compared with wild type, shows an unchanged Vmax but a markedly increased Km for its substrate in the presence of an inhibitor that does not bind the free enzyme. The inhibitor binds only the enzyme-substrate complex. This pattern of inhibition is best classified as?
ANon-competitive inhibition
BCompetitive inhibition
CUncompetitive inhibition
DMixed inhibition