Local Anaesthetic Agents — Topic Test
14 questions · exam mode (answers revealed at the end). 18 min suggested.
A 55-year-old diabetic on metformin is scheduled for elective hernia repair. Regarding the local anaesthetic agents, which property correctly explains why bupivacaine is more cardiotoxic than lignocaine?
ALower lipid solubility limiting myocardial penetration
BHigher pKa causing slower onset
CGreater degree of plasma protein binding reducing free fraction
DSlow dissociation from cardiac sodium channels during diastole