Local Anaesthetics

Local anaesthetics (LAs) are drugs that reversibly block nerve conduction in a circumscribed region when applied locally, producing loss of sensation without loss of consciousness. They are a perennial favourite in NEET PG because they combine a clean mechanism (voltage-gated Na⁺ channel block), neat structure-based classification (ester vs amide), and high-yield clinical correlations (toxicity, adrenaline, different…