Paget's Disease of Bone
HardOrthopaedics · Metabolic Bone
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Paget's disease (osteitis deformans) is a localised disorder of accelerated, disorganised bone remodelling. Excessive osteoclastic resorption is followed by chaotic compensatory osteoblastic formation, producing bone that is enlarged, structurally weak, hypervascular and prone to deformity, fracture and—rarely—malignant transformation. High-yield: The classic biochemical signature is a markedly raised serum alkalin…
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