Pancreatic & Biliary Secretion — Practice
A 6-month-old infant is investigated for failure to thrive and a fasting study shows inappropriately high insulin with hypoglycaemia. In a normal pancreatic beta cell, the immediate trigger that links a rise in the ATP/ADP ratio to insulin secretion is which event?
AClosure of ATP-sensitive K+ channels causing membrane depolarisation
BInhibition of the Na+/K+ ATPase
COpening of voltage-gated K+ channels
DDirect activation of L-type Ca2+ channels by glucose