Polycythaemia Vera & Myeloproliferative Disorders
ModerateMedicine · Haematology
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The classic BCR-ABL-negative myeloproliferative neoplasms (MPNs) — polycythaemia vera (PV), essential thrombocythaemia (ET) and primary myelofibrosis (PMF) — are clonal stem-cell disorders unified by overactive JAK-STAT signalling, most often driven by the JAK2 V617F mutation. They sit on a spectrum: too many red cells (PV), too many platelets (ET) or marrow scarring with extramedullary haematopoiesis (PMF), all shar…
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