Renal Regulation of Sodium & Potassium
ModeratePhysiology · Renal
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The kidney is the master organ of sodium and potassium homeostasis, sensing "effective circulating volume" and adjusting tubular handling segment by segment. This note integrates the physiology of aldosterone, ENaC, ROMK, natriuretic peptides, and the channelopathies (Bartter vs Gitelman) that NEET PG loves to test. Filtered sodium (~180 L/day GFR × 140 mEq/L ≈ 25,000 mEq) is reabsorbed segmentally; less than 1% i…
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